pronounced as (sil den' a fil)
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about storage and disposal of this medication?
- In case of emergency/overdose
- What other information should I know?
- Brand names
Why is this medication prescribed?
Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve the ability to exercise in adults with pulmonary arterial hypertension (PAH; high blood pressure in the vessels carrying blood to the lungs, causing shortness of breath, dizziness, and tiredness). Children should not usually take sildenafil, but in some cases, a doctor may decide that sildenafil (Revatio) is the best medication to treat a child's condition. Sildenafil is in a class of medications called phosphodiesterase (PDE) inhibitors. Sildenafil treats erectile dysfunction by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Sildenafil treats PAH by relaxing the blood vessels in the lungs to allow blood to flow easily.
If you are taking sildenafil to treat erectile dysfunction, you should know that it does not cure erectile dysfunction or increase sexual desire. Sildenafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).
How should this medicine be used?
Sildenafil comes as a tablet and suspension (liquid; Revatio only) to take by mouth.
If you are taking sildenafil to treat erectile dysfunction, follow your doctor's directions and the guidelines in this paragraph. Take sildenafil as needed before sexual activity. The best time to take sildenafil is about 1 hour before sexual activity, but you can take the medication any time from 4 hours to 30 minutes before sexual activity. Sildenafil usually should not be taken more than once every 24 hours. If you have certain health conditions or are taking certain medications, your doctor may tell you to take sildenafil less often. You can take sildenafil with or without food. However, if you take sildenafil with a high-fat meal, it will take longer for the medication to start to work.
If you are taking sildenafil to treat PAH, follow your doctor's directions and the guidelines in this paragraph. You will probably take sildenafil three times a day with or without food. Take sildenafil at around the same times every day, and space your doses about 4 to 6 hours apart.
Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sildenafil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Shake the liquid well for 10 seconds before each use to mix the medication evenly. Use the oral syringe provided with your medication to measure and take your dose. Follow the manufacturer's directions to use and clean the oral syringe. Do not mix the liquid with other medications or add anything to flavor the medication.
If you are taking sildenafil for erectile dysfunction, your doctor will probably start you on an average dose of sildenafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if sildenafil is not working well or if you are experiencing side effects.
If you are taking sildenafil for PAH, you should know that sildenafil controls PAH but does not cure it. Continue to take sildenafil even if you feel well. Do not stop taking sildenafil without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.
Other uses for this medicine
This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking sildenafil,
- tell your doctor and pharmacist if you are allergic to sildenafil, any other medications, or any of the ingredients in sildenafil products. Ask your pharmacist for a list of the ingredients.
- do not take sildenafil if you are taking or have recently taken riociguat (Adempas) or nitrates (medications for chest pain) such as isosorbide dinitrate (Isordil), isosorbide mononitrate (Monoket), and nitroglycerin (Minitran, Nitro-Dur, Nitromist, Nitrostat, others). Nitrates come as tablets, sublingual (under the tongue) tablets, sprays, patches, pastes, and ointments. Ask your doctor if you are not sure whether any of your medications contain nitrates.
- do not take street drugs containing nitrates such as amyl nitrate and butyl nitrate ('poppers') while taking sildenafil.
- tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: alpha blockers such as alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), tamsulosin (Flomax, in Jalyn), and terazosin; amlodipine (Norvasc, in Amturnide, in Tekamlo); certain antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole (Nizoral); anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain barbiturates such as butalbital (in Butapap, in Fioricet, in Fiorinal, others) and secobarbital (Seconal); beta blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide), and propranolol (Hemangeol, Inderal LA, InnoPran); bosentan (Tracleer); cimetidine ; efavirenz (Sustiva, in Atripla); erythromycin (E.E.S., E-Mycin, Erythrocin); HIV protease inhibitors including amprenavir (Agenerase; no longer available in the U.S.), atazanavir (Reyataz, in Evotaz), darunavir (Prezista, in Prezcobix), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (in Kaletra), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra), saquinavir (Invirase), and tipranavir (Aptivus); nevirapine (Viramune); other medications or devices to treat erectile dysfunction; medications for high blood pressure; certain medications for seizures including carbamazepine (Carbatrol, Epitol, Tegretol, others), phenobarbital, and phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sildenafil, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- tell your doctor what herbal products you are taking or plan to take, especially St. John's wort.
- tell your doctor if you smoke, if you have ever had an erection that lasted for several hours, and if you have recently lost a large amount of body fluids (dehydration). This can happen if you are sick with fever, diarrhea, or vomiting; sweat a lot; or do not drink enough liquids. Also tell your doctor if you have or have ever had pulmonary veno-occlusive disease (PVOD; blockage of veins in the lungs); a stomach ulcer; heart, kidney, or liver disease; a heart attack; an irregular heartbeat; a stroke; chest pain; high or low blood pressure; high cholesterol; a bleeding disorder; blood circulation problems;blood cell problems such as sickle cell anemia (a disease of the red blood cells), multiple myeloma (cancer of the plasma cells), or leukemia (cancer of the white blood cells); conditions affecting the shape of the penis (e.g., angulation, cavernosal fibrosis, or Peyronie's disease); or diabetes. Also tell your doctor if you or any of your family members have or have ever had an eye disease such as retinitis pigmentosa (an inherited eye condition that causes loss of vision) or if you have ever had sudden severe vision loss, especially if you were told that the vision loss was caused by a blockage of blood flow to the nerves that help you see.
- if you are a woman and you are taking sildenafil to treat PAH, tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking sildenafil, call your doctor.
- if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking sildenafil.
- if you are taking sildenafil to treat erectile dysfunction, tell your doctor if you have ever been advised by a healthcare professional to avoid sexual activity for medical reasons or if you have ever experienced chest pain during sexual activity. Sexual activity may be a strain on your heart, especially if you have heart disease. If you experience chest pain, dizziness, or nausea during sexual activity, call your doctor immediately and avoid sexual activity until your doctor tells you otherwise.
- tell all your healthcare providers that you are taking sildenafil. If you ever need emergency medical treatment for a heart problem, the healthcare providers who treat you will need to know when you last took sildenafil.
What special dietary instructions should I follow?
Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine.
What should I do if I forget a dose?
If you are taking sildenafil for erectile dysfunction, you are unlikely to miss a dose since this medication is taken as needed, not on a regular dosing schedule.
If you are taking sildenafil for PAH, take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
Sildenafil may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- headache
- heartburn
- diarrhea
- flushing (feeling of warmth)
- nosebleeds
- difficulty falling asleep or staying asleep
- numbness, burning, or tingling in the arms, hands, feet, or legs
- muscle aches
- changes in color vision (seeing a blue tinge on objects or having difficulty telling the difference between blue and green)
- sensitivity to light
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
- sudden severe loss of vision (see below for more information)
- blurred vision
- sudden decrease or loss of hearing
- ringing in ears
- dizziness or lightheadedness
- fainting
- chest pain
- worsening shortness of breath
- erection that is painful or lasts longer than 4 hours
- itching or burning during urination
- rash
Some patients experienced a sudden loss of some or all of their vision after they took sildenafil or other medications that are similar to sildenafil. The vision loss was permanent in some cases. It is not known if the vision loss was caused by the medication. If you experience a sudden loss of vision while you are taking sildenafil, call your doctor immediately. Do not take any more doses of sildenafil or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor.
There have been reports of heart attack, stroke, irregular heartbeat, bleeding in the brain or lungs, high blood pressure, and sudden death in men who took sildenafil for erectile dysfunction. Most, but not all, of these people had heart problems before taking sildenafil. It is not known whether these events were caused by sildenafil, sexual activity, heart disease, or a combination of these and other causes.Talk to your doctor about the risks of taking sildenafil.
Some patients experienced a sudden decrease or loss of hearing after they took sildenafil or other medications that are similar to sildenafil. The hearing loss usually involved only one ear and did not always improve when the medication was stopped. It is not known if the hearing loss was caused by the medication. If you experience a sudden loss of hearing, sometimes with ringing in the ears or dizziness, while you are taking sildenafil, call your doctor immediately. If you are taking sildenafil (Viagra) for erectile dysfunction, do not take any more doses of sildenafil (Viagra) or similar medications such as tadalafil (Cialis) or vardenafil (Levitra) until you talk to your doctor. If you are taking sildenafil (Revatio) for PAH, do not stop taking your medication until you talk to your doctor.
Sildenafil may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about storage and disposal of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the tablets at room temperature and away from excess heat and moisture (not in the bathroom). Store the suspension at room temperature or in a refrigerator, but do not freeze it. Dispose of any unused suspension after 60 days.
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
What other information should I know?
Keep all appointments with your doctor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Brand names
- Revatio®
- Viagra®
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FAQs
What are the dangers of sildenafil? ›
- Headaches. Make sure you rest and drink plenty of fluids. ...
- Feeling sick (nausea) It may help if you avoid rich or spicy food. ...
- Flushing including hot flushes. Try cutting down on coffee, tea and alcohol. ...
- Indigestion. ...
- Stuffy nose. ...
- Feeling dizzy.
By controlling the enzyme, sildenafil helps to maintain an erection after the penis is stroked. Without physical action to the penis, such as that occurring during sexual intercourse, sildenafil will not work to cause an erection.
How long does sildenafil keep you erect for? ›Most men affected by erectile dysfunction who use Viagra are able to get and maintain an erection without any issues for approximately four hours after taking this medication.
What is the difference between 50mg and 100mg of sildenafil? ›There is not a great deal of difference between Sildenafil 100mg and 50mg, although in clinical trials, the higher dosage was seen to be 82% effective, as opposed to 74% effective. The effects of Sildenafil 100mg do not last longer than the 50mg dosage, but they tend to be stronger.
Does sildenafil hurt your heart? ›According to extensive data available to date, sildenafil citrate has been shown to pose minimal cardiovascular risks to healthy people taking this drug. Some precautions are needed for patients with cardiovascular diseases.
Can you take sildenafil for life? ›The short answer is yes; you can take Viagra or its generic form, sildenafil, every day. Whether you need to or should, depends. Since each person is different, you should consult with a doctor about what's best for you. They can discuss dosage and frequency.
When is the best time to take sildenafil? ›Take sildenafil up to 4 hours before you want to have sex. For sildenafil to work properly, you'll need to be sexually excited.
How long can the average man stay erect? ›Typically, an average erection may last from a few minutes to roughly half an hour. However, this can vary significantly due to the many factors that can affect erection duration. It is also worth noting that a person does not need an erection to achieve orgasm.
What happens if you take sildenafil without having ED? ›Nothing much would happen if someone without erectile dysfunction took Viagra, although they might think they feel better psychologically. But it would make a difference if you took it along with other drugs.
How should I take sildenafil for best results? ›Take Viagra 30-60 Minutes Before Sex
The precise amount of time required for Viagra or generic sildenafil to start taking action varies based on a variety of factors, from your diet to your personal drug metabolism.
How long does sildenafil take to peak? ›
In healthy volunteers, sildenafil doses are absorbed rapidly, with maximum plasma concentrations achieved within a median time of 1 h (range, 0.5–2 h) after dosing [3].
What would cause sildenafil not to work? ›Viagra and other PDE5 inhibitors won't work well if your testosterone levels are too low. Testosterone therapy alongside or instead of an ED medication may be a treatment to consider. Your healthcare provider should be able to test testosterone levels and evaluate this with you.
Can I take half of sildenafil 100mg? ›Erectile dysfunction (ED) medications that can be cut in half. The most common ED medications can be safely split. This includes: Sildenafil (Viagra)
How long does sildenafil 100mg last for? ›Sildenafil starts working within 30–60 minutes. Some men find that it works even faster. You should take sildenafil between 30 minutes and four hours before sexual activity. The medication usually stays in your system for 4–5 hours (Zucchi, 2019; DailyMed, 2020).
What happens if I take sildenafil 100mg? ›If you have erectile dysfunction and want to treat it, erectile dysfunction medication like sildenafil can offer numerous benefits. Sildenafil starts working quickly — typically in one hour or less. When it's taken as prescribed, it can provide relief from erectile dysfunction that lasts for approximately four hours.
Who Cannot take sildenafil? ›To make sure it's safe for you, speak to your doctor or pharmacist before taking sildenafil if you: have ever had an allergic reaction to sildenafil or any other medicine. are taking medicines called nitrates for chest pain (angina) have a serious heart or liver problem.
What happens if you take sildenafil with high blood pressure? ›Erectile dysfunction drugs and high blood pressure
Erectile dysfunction drugs include sildenafil (Viagra), vardenafil (Levitra, Staxyn) and tadalafil (Cialis). The pill forms are generally considered safe for men with high blood pressure who are in otherwise good health.
It may be informed from the present study that Sildenafil citrate and ethanol consumption appeared to contribute to enhance higher cholesterol, higher triglycerides, lower HDL, higher LDL and higher VLDL, all of which may attribute increased risk of cardiovascular diseases (Seo et al., 2004).
What happens if you take sildenafil everyday? ›Daily Use of Sildenafil
It is considered safe and effective and, for most people, it causes only mild side effects. Those side effects could include headaches, dizziness and rashes, among other symptoms. If you experience any side effects, it's a good idea to talk to a healthcare provider.
We show that chronically inhibiting cGMP hydrolysis with the phosphodiesterase-5 inhibitor sildenafil improves energy balance and enhances in vivo insulin action in a mouse model of diet-induced insulin resistance.
Can I take sildenafil with alcohol? ›
Alcohol (Ethanol) sildenafil
You may be more likely to experience symptoms such as dizziness, lightheadedness, fainting, flushing, headache, and heart palpitations. You should avoid or limit the use of alcohol while being treated with sildenafil, and use caution when getting up from a sitting or lying position.
Results In comparison to placebo, a single 50-mg dose of sildenafil significantly increased the percentage of total sleep time with an arterial oxygen saturation of less than 90% (mean ± SD, 14.2% ± 9.1% vs 8.5% ± 3.2%, P<.
Why do men get morning wood? ›Your testosterone level is at its highest in the morning after you wake up. It is highest immediately after waking up from the rapid eye movement (REM) sleep stage. The increase in this hormone alone may be enough to cause an erection, even in the absence of any physical stimulation.
How do you stay hard after I come? ›If you're able to stop from expelling semen during sex you may be able to experience a “dry orgasm” and continue to stay erect. Another technique is called edging. Again, edging requires discipline and some practice to perfect. Basically, pay close attention to your body in the 20 seconds before you ejaculate.
How often do guys get hard a day? ›People with penises have an average of 11 erections per day and three to five more each night, but everyone is different. There are numerous factors that can affect how often you get hard, like your age, hormone levels, and lifestyle.
Does sildenafil work without arousal? ›Viagra is a popular medication that's used to help you achieve and maintain an erection — but it only works if you're aroused. You can take Viagra 30 minutes to up to 4 hours before sexual activity, but it shouldn't be taken more than once daily. Viagra is available as a lower-cost generic.
How can I speed up the effects of sildenafil? ›Is it possible to speed up the effects of Viagra? No, there isn't a way to speed up the effects of Viagra. These tablets need to be processed in your digestive system to take effect and even if you crush or chew the pill, the time it takes for your body to fully process the pill stays about the same.
How do you know if sildenafil is working? ›Viagra doesn't start working immediately after taking it, as the medication needs time to be absorbed into your blood. For most men, it takes around 30 minutes before you start to feel the effects of Viagra. 12 minutes after – One study has shown that some men got an erection just 12 minutes after taking Viagra.
What happens if sildenafil doesn't work the first time? ›If it doesn't work, consider talking to your doctor about switching to a higher dose. Often, Viagra will become more effective after a few tries as you become more comfortable with the medication and confident in its effects.
How many mg of sildenafil do I need? ›Adults—5 or 20 milligrams (mg) three times a day. Each dose should be taken about 4 to 6 hours apart. Children—Use and dose must be determined by your doctor.
How long does 50mg of sildenafil stay in your system? ›
Sildenafil has a 4-hour 'half-life', meaning half of the drug has left the bloodstream after 4 hours. Some men may still be able to achieve a satisfactory erection after 10 hours, although the duration will become shorter. After 24 hours all traces of the drug in the bloodstream has practically gone.
When should sildenafil not be taken? ›Sildenafil should not be used with any other medicine or device that causes erections. It is important to tell your doctor about any heart problems you have now or may have had in the past. This medicine can cause serious side effects in patients with heart problems.
When should you not take sildenafil? ›To make sure it's safe for you, speak to your doctor or pharmacist before taking sildenafil if you: have ever had an allergic reaction to sildenafil or any other medicine. are taking medicines called nitrates for chest pain (angina) have a serious heart or liver problem.
Can sildenafil cause blood clots? ›Viagra helps stimulate erections by increasing levels of cGMP -- which is also involved in blood clotting. Therefore, by increasing levels of cGMP, Viagra may actually increase the risk of blood clots, according to the researchers.
How often can you take sildenafil safely? ›Do not take it more than once a day. The dose can be increased to 100mg or decreased to 25mg depending on its effect. Take sildenafil up to 4 hours before you want to have sex. For sildenafil to work properly, you'll need to be sexually excited.
How long does it take for sildenafil to kick in? ›This medicine usually begins to work for erectile dysfunction within 30 minutes after taking it. It continues to work for up to 4 hours, although its action is usually less after 2 hours. Use only the brand of this medicine that your doctor prescribed. Different brands may not work the same way.
Can sildenafil cause stroke? ›This case report further emphasize that stroke is, although rare, real side effect of sildenafil. Potential users should be warned before taking it, especially if they have other stroke risk factors, as recommended by the manufacturer.
Why is my sildenafil not working? ›There are several reasons Viagra and other ED drugs might not work effectively as treatments for erectile dysfunction. These include using Viagra incorrectly, taking a low dose of Viagra and using Viagra to treat ED that's caused by something other than poor blood flow.