Melanotan Injections | Before & After, Side Effects | Nanotech Project (2023)

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What is Melanotan?

How does Melanotan Work?

Melanotan 1 Vs Melanotan II

Melanotan 1 Benefits

1) Induces skin tanning within days

2) Protects against hypertension

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3) Approved to treat solar urticaria

4) Clears skin lesions associated with Hailey-Hailey disease

Melanotan 2 Benefits

1) Stimulates erections in men with ED

2) Induces sunless tanning within 2 weeks

3) Enhances sexual function in females

4) Might cause weight loss

Dosage Information

Melanotan 1 Dosage

Melanotan 2 Dosage

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Frequently Asked Questions

Should you take Melanotan 1 or Melanotan 2?

What are the side effects of Melanotan I?

What are the side effects of Melanotan 2?

Can Melanotan prevent skin cancers?


Melanotan is an analog of alpha-melanocyte stimulating hormone (a-MSH). Alpha-MSH is a naturally produced brain chemical. It is known for stimulating the production and release of melanin, a natural skin pigment that provides pigmentation to your skin, eyes, and hair.

This article will tell you everything you need to know about Melanotan. We’ll kick things off by explaining what this peptide is and how it works in the body. Next, we’ll compare its two forms and discuss their benefits, side effects, and dosages. Read on to know more.

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What is Melanotan?

Melanotan Injections | Before & After, Side Effects | Nanotech Project (1)

Melanotan is a synthetic peptide with multiple amino acids in its chain. As stated above, it is an analog of the naturally-occurring alpha-MSH. Melanotan can be purchased in the form of nasal sprays or subcutaneous injections from the market without a prescription.

Melanotan is primarily used for skin tanning. It also increases sexual arousal in males and females with sexual dysfunction. Melanotan can promote spontaneous erections in men with organic erectile dysfunction (OED) or psychogenic erectile dysfunction (PED), making it a phenomenal research chemical to pair with something like PT-141 for example.

How does Melanotan Work?

Melanotan Injections | Before & After, Side Effects | Nanotech Project (2)

Melanotan works by binding to melanocortin receptors (MCRs) in the body. Also known as melanocytes, MCRs are cells in the skin and eyes. These receptors regulate sexual function, pigmentation, and inflammation. There are five melanocytes in the human body.

Different forms of Melanotan (explained below) bind to different MCRs. Melanotan I (MT 1) has a strong affinity for the MC1R and stimulates it to increase the production of melanin. In contrast, Melanotan II (MT-II) binds to three melanocytes (MC1R, MC3R, and MC5R). [R][R]

This is why many bodybuilders choose to combine their SARMs with melanotan as well, because it will help you get nice and tan, so your muscle striations show better and you look extra jacked.

Melanotan 1 Vs Melanotan II

Melanotan Injections | Before & After, Side Effects | Nanotech Project (3)

Melanotan comes in two forms: Melanotan 1 and Melanotan II.

Melanotan I can induce tanning and lower blood pressure in healthy adults. It has been in a phase I clinical study as a potential treatment for skin cancer caused by harmful UV rays. Furthermore, the European Commission has approved MT 1 for treating solar urticaria. [R]

Melanotan II has been shown to promote erections in men with erectile dysfunction.

In clinical studies, low doses of this drug induced significant tanning within only 5 days. Preclinical studies have shown that MT-II can cause fat loss without requiring you to watch your diet.

Melanotan 1 Benefits

Melanotan Injections | Before & After, Side Effects | Nanotech Project (4)

Since its initial development in the 1980s, Melanotan 1 has attracted various clinical trials. These human studies have shown that MT1 can cause sunless tanning, reduce high blood pressure (hypertension), and reverse skin damage caused by various skin diseases.

Here are the proven benefits of Melanotan I:

1)Induces skin tanning within days

In a clinical study involving six males and one female, MT 1 treatment (0.16 mg/kg daily) for 14 days induced significant tanning on the face, neck, and forearm. Another trial showed that tanning was achieved after only 10 days. Side effects were mild in both studies. [R][R]

Three phase 1 trials investigated whether this synthetic melanotropic peptide could cause tanning in combination with solar UV rays. Results from the three studies show that MT 1 can be safely combined with sun exposure or UV-B rays to induce skin tanning. [R]

2)Protects against hypertension

Hypertension or high blood pressure kills approximately 10 million people every year. It does that via various diseases, including heart attack, kidney problems, and stroke. [R]

In a preclinical study, Melatonin II protected the subjects against deoxycorticosterone acetate (DOCA)-salt-induced hypertension. These results are highly encouraging because DOCA salt-induced hypertension model has been used to study high blood pressure since the 1970s. [R][R]

3)Approved to treat solar urticaria

Solar urticaria is a rare condition in which rash or hives appear on the skin exposed to the sun. In very few cases, solar urticaria can lead to anaphylaxis, which may kill you.

In July 2009, the European Commission granted MT-1 ‘orphan’ designation for the treatment of solar urticaria in the United Kingdom. The orphan designation is granted to medicines intended to treat a rare condition. It helps save the drugs from competition on the market. [R][R]

4)Clears skin lesions associated with Hailey-Hailey disease

The Hailey-Hailey disease is a rare genetic disorder. It is caused when skin cells fail to stick together and symptoms include blisters and erosions on various body parts.

In a phase II open-label study, MT-II treatment (16 mg/day) for 60 days fully cleared skin lesions caused by Hailey-Hailey disease. What is equally encouraging is that both patients experienced no side effects. Plus, for 8 months after treatment, the disease didn’t recur. [R]

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Melanotan 2 Benefits

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Similar to Melanotan I, MT-II has also attracted multiple clinical trials over the years. In these studies, MT-II has shown the potential to stimulate erections in men with ED. MT II has also exhibited the ability to induce sunless tanning and enhance sexual function in males.

Here are the proven benefits of MT II:

1)Stimulates erections in men with ED

According to a double-blind, placebo-controlled study, MT-II injections (0.025 mg/kg of body weight) produced erections in 17 of 20 men with erectile dysfunction. [R]

Two things from this study make one conclude that MT-II can be a potent initiator of penile erection in men with ED. These include its ability to initiate erections on its own (without any sexual stimulation) and the absence of severe side effects. Nausea and yawning were frequently reported.

2)Induces sunless tanning within 2 weeks

In a placebo-controlled crossover study, Melatonin II injections (once every other day for 2 weeks) induced darkened skin in three adult male subjects. [R]

Authors conducting the study recommended dosage of 0.025 mg/kg/day for future studies. They also reported that none of the subjects reported any adverse effects on 6 months of follow-up. Plus, during the study, there was no nausea or decreased appetite.

3)Enhances sexual function in females

Research has shown that MT-II works at the level of the brain to enhance sexual function in females (increased levels of libido and genital arousal). [R]

Unlike other sexual-enhancement drugs, such as Viagra, MT-II doesn’t produce undesirable side effects like increased blood pressure or hypertension. Plus, since it acts on the brain, you don’t need any sexual stimulation for this drug to work.

4)Might cause weight loss

Just as Melanotan I induced fat loss in an animal model, MT-II chronically reduced body mass in animals without the requirements of long-term caloric restriction. [R]

In plain English, that means that MT II is capable of helping you lose weight without forcing you to put an upper limit on your daily caloric intake. Yet, to get the best results out of any weight loss drug, it’s recommended to keep an eye on what you’re eating.

Dosage Information

Melanotan Injections | Before & After, Side Effects | Nanotech Project (6)

Melanotan 1 Dosage

In clinical studies, a 0.25 mg daily dose has been used for sunless tanning. Keep in mind that this (or any other) dosage won’t give immediate results. It may take at least three weeks of administering MT I to see results in the form of darkened skin complexion.

Melanotan 2 Dosage

Different Melanotan 2 dosages have been used in different studies, including:

  • For tanning. 0.025 mg/kg/day
  • For erections. 0.025 mg/kg/day

Frequently Asked Questions

Melanotan Injections | Before & After, Side Effects | Nanotech Project (7)

Should you take Melanotan 1 or Melanotan 2?

Given that it’s approved by the European Commission for the treatment of various skin diseases, Melanotan I might be a better option for beginners who haven’t used peptides before.

What are the side effects of Melanotan I?

In multiple clinical studies, Melanotan I has exhibited a fairly tolerable safety profile. Nausea, yawning, and drowsiness were the most frequently reported side effects.

What are the side effects of Melanotan 2?

Mild nausea, not requiring antiemetic treatment, is the most commonly reported adverse effect in Melanotan II studies.

Can Melanotan prevent skin cancers?

Although Melanotan was developed to prevent skin cancer, no clinical research has confirmed that it is capable of preventing skin cancers. Speak to a qualified medical health professional to know more about Melanotan 1 and other prescription medicines.


Melanotan Injections | Before & After, Side Effects | Nanotech Project (8)

Melanotan is a superpotent cyclic melanotropic peptide that increases melanin production in the body. In both its forms, it has been shown to induce sunless tanning, stimulate penile erections in men with erectile dysfunction, and enhance sexual function in women.

If you’re looking to buy some, we recommend you get the Melanotan for sale from PureRawz, because every batch is 3rd party verified for the utmost purity, and they’re our favorite company that sells it.

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Just be sure to use the code “MD15” and you’ll save 15% off your entire order of Melanotan. If you have any questions about this compound, feel free to ask us in the comments section below!


What is a bad reaction to melanotan? ›

Risks to consumers

Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

How long do the side effects of melanotan 2 last? ›

Side effects of melanotan II

Reduced appetite, nausea and vomiting. In males, spontaneous erections 1-5 hours after administration (priapism), associated with yawning and stretching complex.

Does melanotan 2 affect kidneys? ›

Melanotan II is a non-selective melanocortin-receptor agonist and its effect on humans is an increasing of skin pigmentation, producing of spontaneous penile erection and sexual stimulation. Melanotan II inducing rhabdomyolysis and renal failure have been described previously.

Does melanotan 2 cause anxiety? ›

According to Dr Wedgeworth the side effects of melanotan II can include: nausea, abdominal pain, anxiety, flushing, dizziness, headaches and stomach pain.

Can you give 2 examples of adverse effects to a cosmetic tanning treatment? ›

adverse reaction appearance and management in relation to cosmetic tanning services: burning sensations. coughing. fainting.

Can tanning injections make you ill? ›

All melanin injections are unsafe when used for the purpose of changing skin color. Melanin injections are unregulated and have the potential to cause life threatening side effects. Illegally purchased injections bought online may be mislabeled or contain impurities that could be seriously harmful to your health.

How long do tanning shots stay in your system? ›

Also, bear in mind, when you stop using tanning injections your tan will fade completely within four to eight weeks. The above-mentioned benefits will also soon start to disappear.

Does Melanotan affect your heart? ›

The beneficial effects of leptin and melanotan II are associated with an increase in cardiac mitochondrial oxidative metabolism and respiration, as well as with improved cardiomyocyte calcium coupling, leading to improved cardiac contractile function.

What is the half life of melanotan II? ›

Melanotan-II (MT-II) is an analogue of α-melanocyte stimulating hormone with a modified cyclical structure and half-life of approximately 2 hours [20].

What are the disadvantages of tan enhancer? ›

Psoralen should only be used under medical supervision to treat skin problems such as psoriasis. Using tan accelerators for a long time has been found to increase the risk of skin cancer. When taken by mouth, the possible side effects of tan accelerator products include nausea, headaches and itchy skin.

Why is Melanotan 2 banned? ›

Research has linked melanotan II to conditions including skin cancer and kidney infarction. Experts say that people should avoid unregulated tanning products, and regulators should do more to raise public awareness about their dangers.

Does Melanotan 2 cause weight loss? ›

“Our data show that Melanotan II produces a long-lasting weight loss without the need of maintaining caloric restriction.

What are the positive effects of Melanotan 2? ›

Melanotan-II is given as a shot to produce erections in men with ED (erectile dysfunction), tan the skin, and prevent skin cancers caused by sun exposure.

Is Melanotan toxic? ›

The acute toxicity of melatonin, as observed in both animal and human studies, is remarkably low. Melatonin may cause minor adverse drug reactions, such as headache, insomnia, rash, gastritis, and nightmares at supraphysiological doses.

Does Melanotan 2 raise blood pressure? ›

The increases in cavernosal pressure produced by the high dose of MT-II was accompanied by slight but significant reduction in blood pressure (Figure 3).

What diseases are linked to tanning? ›

The Risks of Tanning
  • Sunburn.
  • Sun Tan.
  • Premature Aging/Photoaging.
  • Skin Cancer.
  • Actinic or Solar Keratoses.
  • Eye Damage. Photokeratitis. Cataracts.
  • Immune System Suppression.
  • More Information.
May 16, 2023

What are the positive effects of tanning? ›

Several health benefit claims such as improved appearance, enhanced mood, and increased vitamin D levels have been attributed to tanning. Furthermore, the Indoor Tanning Association claims that “catching some rays may lengthen your life” [5]. Exposure to sunlight has been linked to improved energy and elevated mood.

Can tanning cause permanent damage? ›

Tanning without burning can still cause skin damage, premature skin ageing and skin cancer. UV radiation can cause permanent DNA damage. Each time you expose your skin to UV radiation you increase your risk of developing skin cancer. People of all skin types are at risk of skin damage, premature ageing and skin cancer.

Why did I get sick after tanning? ›

Sun poisoning is a type of severe sunburn that can cause symptoms like nausea, vomiting, fever, and chills. The skin may also blister and peel. Sun poisoning is usually caused by spending too much time in the sun without wearing sunscreen or protective clothing. It can also be caused by using a tanning bed.

What is the difference between Melanotan 1 and Melanotan 2? ›

Melanotan 2 is a shorter cyclic variant of Melanotan 1 that was developed in the 1990's. Melanotan 2 was found to increase skin pigmentation at lower cumulative doses than Melanotan 1. However, in clinical trials it was found to have more side effects including nausea somnolence and penile erections [11].

What is the difference between Melanotan I and II? ›

Melanotan I increases melanogenesis and eumelanin content to produce sunless tanning. Melanotan II also increases skin pigmentation but also produces spontaneous penile erections and sexual stimulation. Bremelanotide is a variation of Melanotan II that is specifically designed for sexual stimulation.

Are tan shots worth it? ›

It also feels smoother than before after getting a sunbed. I've also noticed that my skin isn't breaking out. With all the added vitamins, I don't feel as tired as usual, and feel like I've got a lot more energy. Overall, I would always recommend a tan shot when tanning as you are healing your skin from the inside.

Do tan shots work without sun? ›

tan injections (also known as tan jabs). Sunless tanning refers to the use of chemicals applied to the skin or administered via oral tablets or injections in order to achieve a tan without UV exposure.

Are tanning injections safer than sunbeds? ›

It is safer to use fake tan than to sunbathe or use a sunbed. Remember that neither a fake nor a real tan will protect your skin from the sun.

Does Melanotan cross blood brain barrier? ›

Cyclized melanotropin is a useful strategy for developing MCRs ligands due to their ability to penetrate the blood-brain-barrier.

Does Melanotan make you sleep? ›

Melatonin helps control sleep and waking patterns. It can be taken as a pill to help with sleep problems, including jet lag and insomnia. When it gets dark, the body produces more melatonin to help a person to fall asleep.

Is Melanotan anti inflammatory? ›

Description. Melanotan II is a synthetic melanocortin peptide analog that exhibits thermogenic, anti-inflammatory, and anti-atherosclerotic activities; it non-selectively binds melanocortin receptors.

Does it matter where you inject melanotan 2? ›

Melanotan is administered sub-cutaneously by injecting into the fatty layer of tissue around the belly button area. Clients inject daily until a desired colour is achieved and then continue to inject once or twice a week to maintain the colour.

Does melanotan help with weight loss? ›

If injected or used as a nasal spray, Melanotan-II can cause dramatic skin darkening in just days. The drug can also suppress appetite and lead to weight loss, another effect that some users find desirable.

Is headache a side effect of melanotan 2? ›

The reported adverse effects relate to the location of the receptors are thus wide ranging including nausea, abdominal pain, anxiety, flushing, dizziness, headaches, appetite suppression, stomach pain, cramping, severe constipation, spontaneous penile erections, muscle pain and induction of cancer in the skin.

What is the safest tanning solution? ›

Safer self-tanning options
  • Skinerals Onyx Self Tanner.
  • The Organic Pharmacy Self Tan.
  • Suntegrity Natural Self Tanner.
  • Whish Coconut Milk + Verbena Self Tanner.
  • Isle of Paradise Disco Tan Instant Wash-Off Body Bronzer.
  • Tarte Cosmetics Better Bod Bronze & Contour.
Jun 22, 2021

Why is unlimited tanning not recommended? ›

Cancer Risk

Exposure to UV radiation—whether from the sun or from artificial sources such as sunlamps used in tanning beds—increases the risk of developing skin cancer, according to the National Cancer Institute (NCI).

What is the best tanning accelerator? ›

  • Coco & Eve Tan Activating Body Oil. Coco & Eve. ...
  • James Read Tan Accelerator. James Read. ...
  • Comfort Zone Sun Soul Cream Gel Tan Maximiser. ...
  • Gatineau Tan Accelerating Lotion. ...
  • Elemis Tan Accelerator Supersize. ...
  • Ultrasun Body Tan Activator SPF 30. ...
  • Lancaster Golden Tan Maximizer After Sun Lotion 400ml. ...
  • Skinny Tan Pre Tan Primer.
May 25, 2023

What was Melanotan originally made for? ›

It was originally made as a drug to help treat certain skin conditions. It is also sold over the internet as a supplement. Melanotan is commonly used for skin tanning.

Is melanotan II a steroid? ›

Melanotan-II, Steroid.

Is Melanotan 2 FDA approved? ›

Not FDA approved, but Melanotan II products are currently sold and purchased online. Catalog No.

Does Melanotan cause moles? ›

Melanotan (an unlicensed medicine dubbed the "tan jab") can cause rapid changes in the appearance of moles, warn skin experts in the British Medical Journal. There are two types of Melanotan – Melanotan I and Melanotan II.

Does Melanotan 2 protect your skin? ›

Melanotan as a natural form of photoprotection, meaning it aids in preventing the damage of the sun, was also touted as a way to get tanned without the risk of skin cancer.

Is Melanotan nasal safe? ›

The bottom line is clear: “Melanotan sprays just aren't safe, period,” Dr. Vidimos says. If you're jonesing for a little bit of a glow, though, there's a tried-and-true — and much, much safer — route you can take instead.

What are the long term effects of Melanotan 2? ›

Long term, there is concern that melanotan II may increase the risk of: Melanoma – a potentially serious form of skin cancer. Deepening of the colour of moles, new moles and atypical melanocytic naevi. Melanonychia – brown to black discolouration of one or more nails.

Can you have an allergic reaction to nasal tanners? ›

'Like with most medications, there are side effects and users of nasal tanning sprays have already reported significant side effects, such as nausea, headaches, spontaneous erections, darkening of moles, stomach and heart problems, as well as blood and eye disorders and life-threatening allergic reactions.

What does an allergic reaction to fake tan look like? ›

While natural self tanners contain plant derived, non toxic DHA, if you have a DHA allergy these may still cause skin irritation. A DHA allergic reaction will usually present like hives on the skin; red, swollen and uncomfortable.

What does melanotan 2 do to the heart? ›

The beneficial effects of leptin and melanotan II are associated with an increase in cardiac mitochondrial oxidative metabolism and respiration, as well as with improved cardiomyocyte calcium coupling, leading to improved cardiac contractile function.

How do you know if you're allergic to fake tan? ›

A sign that you may be having a reaction to self-tan is your skin feeling extremely irritated or itchy after application. This can occur instantly or a few hours after you apply it when your skin has adjusted. You may also notice that your skin is drier than usual, resulting in you itching more.

Why do nasal tanners make you feel sick? ›

Dermatologists said nasal tanning sprays can contain melanotan II, a peptide the boosts melanin production. Melanotan II usage can lead to nausea, dizziness, flushing, and changes in appetite.

How long do nasal allergic reactions last? ›

Allergic rhinitis symptoms last as long as you are exposed to the allergen. Cold and flu symptoms generally last 3 to 14 days. The nasal discharge in allergic rhinitis is usually clear. In colds or flu it is more likely to be discolored (yellow.)

How do you treat a nasal allergic reaction? ›

How you can treat allergic rhinitis yourself
  1. antihistamines.
  2. decongestant nasal sprays or drops to unblock your nose (decongestants should not be used by children under 6)
  3. salt water nasal sprays or solutions to rinse out the inside of your nose.

What does a true allergic reaction look like? ›

Skin reactions, including hives and itching and flushed or pale skin. Low blood pressure (hypotension) Constriction of the airways and a swollen tongue or throat, which can cause wheezing and trouble breathing. A weak and rapid pulse.

What does an allergic reaction to make up look like? ›

Allergic reactions can range in severity, but may include hives, itchy skin, a rash, flaking or peeling skin, facial swelling, irritation of the eyes, nose and mouth, wheezing, and anaphylaxis.

What does your face look like after an allergic reaction? ›

Symptoms of an allergic reaction on the face can include: a rash or hives. puffy, raised areas of skin. small, red spots on the skin.

Does it matter where you inject Melanotan 2? ›

Melanotan is administered sub-cutaneously by injecting into the fatty layer of tissue around the belly button area. Clients inject daily until a desired colour is achieved and then continue to inject once or twice a week to maintain the colour.

Is Melanotan carcinogenic? ›

Serious safety concerns have surrounded Melanotan-II since it was first developed at the University of Arizona in the 1990s. Chief among those is the drug's potential to induce melanoma, the deadliest form of skin cancer.

Why do I get an itchy rash after tanning? ›

The itching and bumps you notice may be caused by too much UV light exposure. Your skin also could be sensitive to chemicals used to clean tanning beds or ingredients in cosmetics or lotions. Another less-than-pleasant possibility is you may have a skin infection from a bed that hasn't been cleaned properly.

What does a tanning rash look like? ›

The rash usually appears as tiny, inflamed bumps or slightly raised patches of skin. The reaction usually happens during spring and early summer when exposure to sunlight increases. It's less likely to be repeated as the summer progresses. But the rash often happens again each year after the first time.

Why is my skin sensitive after tanning? ›

The most straightforward cause of a tanning bed rash is dry skin. If you start your tanning session with dry skin, tanning lamps can zap the moisture from the top layer of your skin. This can cause your skin to rebel with itchy, scaly patches. Another cause is ultraviolet (UV) overexposure.


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